HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione → 1-(2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dione | HCID 79720 | — |
| Reactant | Indan-5-amine | HCID 90496 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidine-3-carboxylic acid | HCID 24688697 | 71.7% |
Reaction Steps
This compound was prepared according to general method 1 starting from 6,6-dimethyl-5,7-dioxaspiro[2.5]octane-4,8-dione (0.250 g; 1.45 mmol) and 2,3-dihydro-1H-inden-5-amine (0.593 g; 4.36 mmol) in ethanol (3 mL). 1-(2,3-dihydro-1H-inden-5-yl)-2-oxopyrrolidine-3-carboxylic acid 0.255 g (71%) was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434722B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-dd8884cb3ecb43a8ae271bc771ede609 |
| Source note | uspto-grants-2016_09 |