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HRID 585964作成日：2026年10月25日

1H-Indazol-4-amine, 1-methyl- → N-[3-fluoro-4-(1-piperidinyl)benzyl]-N'-(1-methyl-1H-indazol-4-yl)urea

https://huagongshe.com/reaction/585964

反応式

関与物質

役割名称HCID仕込み量
反応物1H-Indazol-4-amine, 1-methyl-HCID 153838—
反応物NoName_3327HCID 413085—
反応物1-[2-Fluoro-4-(isocyanatomethyl)phenyl]piperidineHCID 22337607—
生成物N-[3-fluoro-4-(1-piperidinyl)benzyl]-N'-(1-methyl-1H-indazol-4-yl)ureaHCID 22337698—

反応手順

The title compound was prepared using the procedure described in Example 89B using 1-[2-fluoro-4-(isocyanatomethyl)phenyl]piperidine and 1-methyl-1H-indazol-4-amine instead of 1-bromo-4-(isocyanatomethyl)benzene and the product from Example 89A. NMR (DMSO-d6) δ 9.19 (s, 1H), 8.22 (s, 1H), 7.25 (m, 4H), 7.18 (d, 2H), 4.31 (s, 2H), 4.00 (s, 3H), 3.15 (m, 4H), 1.77 (m, 4H), 1.66 (m, 2H); MS (ESI) (M+H)+ 382.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06933311B2
出典データセットuspto-grants-2005_08
ORD IDord-b8ba09a05f1540db9b022a01d0002df4
出典メモuspto-grants-2005_08