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Ammonia → N-[1-(4-bromophenyl)ethyl]-2-(5-isoquinolinyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 4-Bromobenzylamine | HCID 77571 | — |
| 反応物 | 1-(4-Bromophenyl)ethylamine | HCID 91175 | — |
| 反応物 | Methyl 2-(isoquinolin-5-yl)acetate | HCID 22337565 | — |
| 生成物 | N-[1-(4-bromophenyl)ethyl]-2-(5-isoquinolinyl)acetamide | HCID 22032664 | — |
反応手順
The title compound was prepared using the procedure described in Example 132C using the product from Example 133B and 1-(4-bromophenyl)ethanamine instead of the product from Example 132B and 4-bromobenzylamine. 1H NMR (300 MHz, d6-DMSO) 9.81 (s, 1H), 9.00 (d, 1H), 8.70 (d, 1H), 8.48 (d, 1H), 8.40 (d, 1H), 8.04 (d, 1H), 7.92 (m, 1H), 7.51 (d, 2H), 7.23 (d, 2H), 4.84 (m, 1H), 4.10 (s, 2H), 1.35 (d, 3H). MS (DCI/NH3) m/e 369 (M+H)+; Anal. Calcd. For C19H17N2OBr.1.0 HCl.1.0H2O: C, 53.86; H, 4.76; N, 6.61. Found: C, 53.47; H, 4.53; N, 6.76.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06933311B2 |
| 出典データセット | uspto-grants-2005_08 |
| ORD ID | ord-74d3570300524c259722f7eb03cdde17 |
| 出典メモ | uspto-grants-2005_08 |