Acetic Anhydride → N-(Isoquinolin-3-yl)acetamide

HRID 586001Notes

Reaction equation

HRID 586001 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.[CH3:12][C:13](OC(C)=O)=[O:14]>>[CH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[C:2]([NH:1][C:13](=[O:14])[CH3:12])[N:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 311869Isoquinolin-3-Amine

Product 1

HCID 12366594N-(Isoquinolin-3-yl)acetamide

Procedure

3-Aminoisoquinoline (495 mg, 3.44 mmol) was stirred in Ac2O (9 mL) at 60° for 16 hours. The mixture was cooled to room temperature and concentrated in vacuo to provide the title compound which was used in the next step without further purification.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-12dc5e35ee0842808f8e98c3eb9a0b39
Source dataset
uspto-grants-2005_08
Patent number
US06933311B2

Reaction notes

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