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HRID 586035作成日：2026年10月25日

2,4-Dichlorobenzylamine → N-(2,4-dichlorobenzyl)-2-(5-isoquinolinyl)propanamide

https://huagongshe.com/reaction/586035

反応式

関与物質

役割名称HCID仕込み量
反応物2,4-DichlorobenzylamineHCID 1485—
反応物2-(Isoquinolin-5-YL)acetic acidHCID 12018708—
反応物2-(Isoquinolin-5-yl)propanoic acidHCID 22337638—
生成物N-(2,4-dichlorobenzyl)-2-(5-isoquinolinyl)propanamideHCID 22337583—

反応手順

The title compound was prepared using the procedure described in Example 222B using 2,4-dichlorobenzylamine and 2-(5-isoquinolinyl)propanoic acid instead of 4-(trifluoromethoxy)benzylamine and 5-isoquinolinylacetic acid. MS (ESI+) m/z 359 (M+H)+; MS (ESI−) m/z 357 (M−H)−; 1H NMR (DMSO, 300 MHz) δ 1.54 (d, J 7.1, 3H), 4.20 (m, 2H), 4.53 (q, J 7.1, 1H), 7.22 (d, J 8.4, 1H), 7.33 (m, 2H), 7.56 (s, 1H), 7.78 (t, J 7.8, 1H), 7.90 (d, J 6.5, 1H), 8.17 (d, J 8.1, 1H), 8.25 (d, J 6.4, 1H), 8.62 (m, 2H), 9.51 (s, 1H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06933311B2
出典データセットuspto-grants-2005_08
ORD IDord-c66f449bb1274b20bfce8faf87d77f50
出典メモuspto-grants-2005_08