反应详情

温度

0 °C

The product from Example 297A (4.00 g, 19.4 mmol) in acetone (9 mL) at 0° C. ws treated with sodium azide (1.27 g) in water (9 mL) dropwise over 15 minutes. after stirring for 30 minutes at 0° C., the mixture was extracted with toluene (20 mL). The toluene solution was dried over MgSO4, filtered, and the filtrate was heated to reflux for 1 hour. The cooled solution was concentrated under reduced pressure to provide the title compound.

1. extractionthe mixture was extracted with toluene (20 mL)
2. dry with materialThe toluene solution was dried over MgSO4
3. filtrationfiltered
4. temperaturethe filtrate was heated
5. temperatureto reflux for 1 hour
6. concentrationThe cooled solution was concentrated under reduced pressure