Sodium Hydroxide → HCID 22337593, compound

HRID 586068Notes

Reaction equation

HRID 586068 reaction equation
[C:1]1([CH2:11][NH:12][C:13]([NH:15][C:16]2[CH:24]=[CH:23][CH:22]=[C:21]3[C:17]=2[CH:18]=[N:19][N:20]3C(OC)=O)=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.O>[NH:20]1[C:21]2[C:17](=[C:16]([NH:15][C:13]([NH:12][CH2:11][C:1]3[C:10]4[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=4)[CH:4]=[CH:3][CH:2]=3)=[O:14])[CH:24]=[CH:23][CH:22]=2)[CH:18]=[N:19]1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 22337645HCID 22337645, compound

Product 1

HCID 22337593HCID 22337593, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Methyl 4-({[(1-naphthylmethyl)amino]carbonyl}amino)-1H-indazole-1-carboxylate in methanol was treated with 5M sodium hydroxide (8 equivalents) (prepared by dissolution of 1 gram of sodium hydroxide in 20 μL of methanol). After stirring for 30 minutes, the mixture was diluted with water (10 mL) and filtered. The filter cake was washed with water (10 mL), water:methanol (1:1), and dried under reduced pressure to provide the title compound. MS (M+H)+ 317.

Workup

  1. filtrationfiltered
  2. washThe filter cake was washed with water (10 mL), water:methanol (1:1)
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-3fe11da8d91c46dcafd412385e5f5e69
Source dataset
uspto-grants-2005_08
Patent number
US06933311B2

Reaction notes

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