HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azepane → 3,5-Difluoro-4-azepan-1-ylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azepane | HCID 8119 | — |
| Reactant | 8-Azabicyclo[3.2.1]octane hydrochloride | HCID 522272 | — |
| Reactant | 3,4,5-Trifluorobenzonitrile | HCID 593814 | — |
| Product | 3,5-Difluoro-4-azepan-1-ylbenzonitrile | HCID 57466750 | — |
Reaction Steps
The title compound was prepared using the procedure described in Example 325A except using 3,4,5-trifluorobenzonitrile and azepane instead of 3,4-difluorobenzonitrile and 8-aza-bicyclo[3.2.1]octane hydrochloride. 1H NMR (DMSO-d6) δ 7.62 (d, 2H), 3.39 (m, 4H), 1.73 (m, 4H), 1.61 (m, 4H); MS (ESI) m/z 237 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06933311B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-1b73734caa914f9d8639f4dec622d544 |
| Source note | uspto-grants-2005_08 |