HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanuric chloride → tert-butyl N-(1-cyanocyclopropyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanuric chloride | HCID 7954 | — |
| Reactant | tert-butyl N-(1-carbamoylcyclopropyl)carbamate | HCID 20825554 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-butyl N-(1-cyanocyclopropyl)carbamate | HCID 20825555 | 53.9% |
Reaction Steps
To a stirred solution of (1-carbamoyl-cyclopropyl)-carbamic acid tert-butyl ester (5.7 g, 28.4 mmol) in DMF (50 mL) was added cyanuric chloride (2.6 g, 14.2 mmol) and it was stirred at room temperature for 1 h before it was diluted with water (400 mL). The product precipitated and filtration gave (1-cyano-cyclopropyl)-carbamic acid tert-butyl ester (2.79 g, 53.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936606B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-d1d8680fe973410481f5015b533c5343 |
| Source note | uspto-grants-2005_08 |