HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphonoacetate → Ethyl (1-methylpiperidin-4-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphonoacetate | HCID 13345 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Ethyl (1-methylpiperidin-4-yl)acetate | HCID 11819748 | — |
Reaction Steps
2-(1-Methyl-piperid-4-yl)-ethanoic acid ethyl ester is prepared from 1-methyl-piperid4-one (1 equiv), triethyl phosphono acetate (1 equiv) and NaH (1.1 equiv) in benzene followed by reduction of the alkene bond according to the procedure of Cignarella etc. (J Heterocyclic Chem 1993, 30 (5), 1337-1340).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936606B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-7c9ed19be62f47e9bd4ec05490ec61e9 |
| Source note | uspto-grants-2005_08 |