(3,5-Dimethoxyphenyl)methanamine → HCID 12052770, compound

HRID 586152Notes

Reaction equation

HRID 586152 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[N:16]=[C:15]([N:17]3[CH:21]=NC=N3)[C:14]3=[C:22]([CH3:26])[N:23]=[C:24]([CH3:25])[N:13]3[N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:34]=[C:35]([O:37][CH3:38])[CH:36]=1)CN>>[CH3:27][O:28][C:29]1[CH:30]=[C:31]([CH:34]=[C:35]([O:37][CH3:38])[CH:36]=1)[CH2:21][NH:17][C:15]1[C:14]2=[C:22]([CH3:26])[N:23]=[C:24]([CH3:25])[N:13]2[N:12]=[C:11]([C:5]2[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)[N:16]=1

Participants

3

Reactant 2

HCID 420973(3,5-Dimethoxyphenyl)methanamineHCID 11268165HCID 11268165, compound

Product 1

HCID 12052770HCID 12052770, compound

Procedure

Prepared analogously to Example 1 from Example 37A (80 mg, 0.23 mmol) and 3,5-dimethoxybenzylamine (396 mg, 2.32 mmol). Purification is carried out by flash chromatography (eluent dichloromethane/methanol 80:1).

Workup

  1. customPurification

Sources & evidence

ORD record
ord-1f654d3cddf24169be342df9cb57c9a6
Source dataset
uspto-grants-2005_08
Patent number
US06936609B2

Reaction notes

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