Triethylamine → N-[4-({[2-(4-Bromophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]amino}-methyl)phenyl]acetamide

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	N-[4-(aminomethyl)phenyl]acetamide	HCID 15295869	—
Reactant	2-(4-Bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine	HCID 22329622	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	N-[4-({[2-(4-Bromophenyl)-5,7-dimethylimidazo[5,1-f][1,2,4]triazin-4-yl]amino}-methyl)phenyl]acetamide	HCID 22329639	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

2-(4-Bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]-triazine (3.7 mg, 10 mmol) is treated in dioxane (100 μl) with 4-acetylamino-benzylamine (3.3 mg, 20 mmol) and triethylamine (4 μl). The mixture is heated at 80° C. with shaking for 12 h, filtered and washed with DMSO (2×100 μl). The combined filtrates are purified chromatographically by preparative LC-MS.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06936609B2
Source dataset	uspto-grants-2005_08
ORD ID	ord-220a3115004a4a9fa2dfcefbfc7be50a
Source note	uspto-grants-2005_08