Dichloromethane → HCID 22329755, compound

Participants

Reaction Steps

4-(2-Methyl-4-(3-pyridyl)benzoyl)piperazine (0.41 g, 1.5 mmol) was dissolved in dichloromethane (50 mL) at room temperature. 6-Chloronaphthalenesulphonyl chloride (0.38 g, 1.5 mmol) and triethylamine (1 ml, 7.5 mmol) were added and the reaction mixture stirred overnight. The reaction mixture was concentrated in vacuo. The crude product was dissloved in EtOAc (100 mL) and washed with saturated sodium hydrogen carbonate solution (100 mL). The EtOAc layer was separated, dried over MgSO4, filtered and concentrated in vacuo. The resulting solid was subjected to chromatography (SiO2: 50%, 60% EtOAc/Hexane) to yield 1-(6-chloronaphth-2-ylsulphonyl)-4-[2-methyl-4-(3-pyridyl)benzoyl]piperazine as a white solid (508.4 mg); 1H NMR (DMSO-d6) δ=2.15 ppm (s,3H), δ=2.94 to 3.25 ppm (m,6H), δ=3.78 ppm (m,2H), δ=7.23 ppm (d,1H), δ=7.44 to 7.62 ppm (m,3H), δ=7.70 ppm (dd,1H), δ=7.84 ppm (dd,1H), δ=8.08 ppm (m,1H), pyridyl 5-H), δ=8.12 to 8.28 ppm (m,3H), δ=8.48 ppm (s,1H), δ=8.59 ppm (dd,1H), δ=8.88 ppm (d,1H); MS (M+H)+ 506.

Provenance & Evidence