反应详情

5′-(5,5-Dimethyl-[1,3,2]dioxaborinan-2-yl)-4,2′-difluorobiphenyl-2-carbonitrile was coupled to 7-bromo-3-(1-fluoro-1-methylethyl)imidazo[1,2-b][1,2,4]triazine in 77% yield using a similar procedure to that described in Example 3, step f, to give a yellow solid: mp 156-159° C. (EtOAc-isohexane); 1H NMR (400 MHz, CDCl3) δ 1.84 (6H, d, J 22.0 Hz), 7.36-7.46 (2H, m), 7.54 (1H, dd, J 7.8, 2.7 Hz), 7.57-7.60 (1H, m), 8.10-8.16 (2H, m), 8.30 (1H, s), 8.79 (1H, d, J 1.2 Hz); MS (ES+) m/z 394 [M+H]+. Anal. Found: C, 64.07; H, 3.66; N, 17.60%. Required for C21H14F3N5: C, 64.12; H, 3.59; N, 17.80%.

1. customto give a yellow solid