反应详情

To a stirred solution of 7-(4-fluoro-3-methoxyphenyl)-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (0.123 g, 0.397 mmol) in chloroform (5 ml) was added boron tribromide (1.19 ml, 1.91 mmol) and the mixture was stirred under nitrogen at room temperature for 21 h. 2 M NaOH (5 ml) was added and the mixture was stirred for 5 min producing a solid which was filtered and washed with water. The filtrate was washed with dichloromethane, and the aqueous layer was neutralised with concentrated hydrochloric acid causing a solid to precipitate. The solid was filtered, washed with water and dried under a vacuum to leave 109 mg (93%) of the title compound: 1H NMR (360 MHz, DMSO-d6) δ 7.38 (1H, dd, J 8.8, 11.2 Hz), 7.60-7.64 (1H, m), 7.88 (1H, dd, J 1.9, 8.6 Hz), 9.32 (1H, s), 10.26 (1H, s); MS (ES+) m/z 299 [M+H]+.

1. stirringthe mixture was stirred for 5 min
2. customproducing a solid which
3. filtrationwas filtered
4. washwashed with water
5. washThe filtrate was washed with dichloromethane
6. customto precipitate
7. filtrationThe solid was filtered
8. washwashed with water
9. customdried under a vacuum