7-Bromo-3-trifluoromethyl-imidazo[1,2-B][1,2,4]triazine → 2'-Fluoro-3'-(3-trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)biphenyl-2-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	7-Bromo-3-trifluoromethyl-imidazo[1,2-B][1,2,4]triazine	HCID 11601416	—
Reactant	(2'-Cyano-2-fluoro-[1,1'-biphenyl]-3-yl)boronic acid	HCID 11644397	—
Product	2'-Fluoro-3'-(3-trifluoromethylimidazo[1,2-b][1,2,4]triazin-7-yl)biphenyl-2-carbonitrile	HCID 10156780	15%

Reaction Steps

7-Bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine was coupled with 2′-cyano-2-fluorobiphenyl-3-boronic acid as described in Example 3, step f, to give 21 mg (15%) of the title compound: mp 167-168° C.; 1H NMR (360 MHz, CDCl3) δ 7.47-7.60 (4H, m), 7.73 (1H, dd, J 1.4, 7.7 Hz), 7.84 (1H, dd, J 0.7, 7.0 Hz), 8.26-8.30 (1H, m), 8.69 (1H, d, J 2.8 Hz), 8.83 (1H, s); MS (ES+) m/z 384 [M+H]+. Anal. Found: C, 59.14; H, 2.75; N, 18.01%. Required for C19H9F4N5.0.2H2O: C, 58.98; H, 2.45; N, 18.10%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06936608B2
Source dataset	uspto-grants-2005_08
ORD ID	ord-125bc075e6cc4c6c80458e941c702f4d
Source note	uspto-grants-2005_08