3-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)pyridine → 3-tert-Butyl-7-[4-fluoro-3-(pyridin-3-yl)phenyl]imidazo[1,2-b][1,2,4]triazine

Participants

Reaction Steps

This compound was prepared in 48% yield as described in the final paragraph of Example 2, step d, but using 7-bromo-3-tert-butylimidazo[1,2-b][1,2,4]triazine instead of 7-bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine, and using 3-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]pyridine (prepared as described in Example 3, step f) instead of 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile: 1H NMR (360 MHz, CDCl3) δ 1.50 (9H, s), 7.34 (1H, m), 7.44 (1H, dd, J 4.9, 8.1 Hz), 7.94-8.02 (2H, m), 8.19 (1H, dd, J 2.5, 7.4 Hz), 8.21 (1H, s), 8.59 (1H, s), 8.66 (1H, d, J 4.82 Hz), 8.88 (1H, s); MS (ES+) m/z 348 [M+H]+. Anal. Found: C, 66.95; H, 5.15; N, 19.00%. Required for C20H18FN5.0.75H2O: C, 66.56; H, 5.45; N, 19.41%.

Provenance & Evidence