2-(7-Bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-ol → PharmaGSID_47330

Participants

Role	Name	HCID	Charge
Reactant	2-(7-Bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-ol	HCID 11207603	—
Reactant	2′,6-Difluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile	HCID 11473289	—
Product	PharmaGSID_47330	HCID 9865233	—

Reaction Steps

6,2′-Difluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-biphenyl-2-carbonitrile was coupled to 2-(7-bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-ol in 32% yield using a similar procedure to that described in Example 3, step f, to give a yellow solid: mp 206° C.; 1H NMR (360 MHz, CDCl3) δ 1.71 (6H, s), 3.28 (1H, br s), 7.37-7.66 (4H, m), 8.15 (2H, m), 8.26 (1H, s), 8.78 (1H, s); MS (ES+) m/z 392 [M+H]+. Anal. Found: C, 64.66; H, 3.93, N, 17.71%. Required for C21H15F2N5O: C, 64.45; H, 3.86; N, 17.89%.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06936608B2
Source dataset	uspto-grants-2005_08
ORD ID	ord-db74c4cbe74a41fb982a96936b5166d5
Source note	uspto-grants-2005_08