反应详情

3-Fluoro-2-(2-fluoro-5-nitrophenyl)pyridine (1.0 g) was dissolved in dichloromethane (25 ml) and diluted with ethanol (50 ml). Platinum oxide (0.1 g) was added, and the mixture shaken on a Parr hydrogenation apparatus under an atmosphere of hydrogen at 45 psi for 4 h. The reaction was filtered and the filtrate evaporated, to afford 4-fluoro-3-(3-fluoropyridin-2-yl)phenylamine, which was used without further purification: 19F NMR (400 MHz, CDCl3) δ 128.48 (1F, d, J 36 Hz), 122.66 (1F, d, J 36 Hz).

1. filtrationThe reaction was filtered
2. customthe filtrate evaporated