HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 2-(5-Bromo-2-fluorophenyl)-3-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-Fluoro-3-(3-fluoropyridin-2-yl)phenylamine | HCID 22329525 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Catalyst | copper(I) bromide | HCID 24593 | — |
| Product | 2-(5-Bromo-2-fluorophenyl)-3-fluoropyridine | HCID 11543587 | — |
Reaction Steps
4-Fluoro-3-(3-fluoropyridin-2-yl)phenylamine was subjected to reaction with sodium nitrite, in hydrobromic acid in the presence of copper(I) bromide, according to the method of Example 23. 2-(5-Bromo-2-fluorophenyl)-3-fluoropyridine was obtained by chromatography (silica gel, CH2Cl2) as a pink solid: MS (ES+) m/z 270, 272 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936608B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-112c0d8dadbb4192b8dcb1c07ebd98c2 |
| Source note | uspto-grants-2005_08 |