2-(7-Bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-ol → HCID 10132583, compound

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Reaction Steps

4-Fluoro-3-(pyridazin-3-yl)phenylboronic acid (50 mg, 0.23 mmol) was coupled to 2-(7-bromoimidazo[1,2-b][1,2,4]triazin-3-yl)propan-2-ol (56 mg, 0.22 mmol) using the method of Example 20. Purification by chromatography (silica gel, 3% MeOH/CH2Cl2) gave the title compound as a yellow solid: 1H NMR (400 MHz, CDCl3) δ 1.72 (6H, s), 7.37 (1H, dd, J 11, 9 Hz), 7.60 (1H, dd, J 9, 5 Hz), 8.04 (1H, dt, J 9, 2 Hz), 8.14-8.19 (1H, m), 8.31 (1H, s), 8.82 (1H, s), 8.90 (1H, dd, J 7, 2 Hz), 9.22 (1H, dd, J 5, 2 Hz); MS (ES+) m/z 351 [M+H]+.

Provenance & Evidence