HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine → 3-(2-Chloropyrimidin-4-yl)-4-fluorophenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine | HCID 22285326 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-Chloropyrimidin-4-yl)-4-fluorophenylamine | HCID 22285292 | — |
Reaction Steps
A solution of 2-chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine (800 mg, 3.2 mmol) in ethanol (300 ml) was reduced under 40 psi hydrogen with platinum(IV) oxide (100 mg) for 30 minutes then filtered to give a solution of 3-(2-chloropyrimidin-4-yl)-4-fluorophenylamine: MS (ES+) m/z 224 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936608B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-12be636d54604724ab1b2060d6f5d224 |
| Source note | uspto-grants-2005_08 |