Bis(neopentyl glycolato)diboron → HCID 22285299, compound

HRID 586293Notes

Reaction equation

HRID 586293 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:14])=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][N:9]=2)[CH:7]=1.[B:15]1(B2OCC(C)(C)CO2)[O:20]CC(C)(C)C[O:16]1>>[F:14][C:5]1[CH:4]=[CH:3][C:2]([B:15]([OH:20])[OH:16])=[CH:7][C:6]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][N:9]=1

Participants

3

Reactant 2

HCID 2734316Bis(neopentyl glycolato)diboronHCID 22285318HCID 22285318, compound

Product 1

HCID 22285299HCID 22285299, compound

Procedure

4-(5-Bromo-2-fluorophenyl)pyrimidine (503 mg, 2.0 mmol) was reacted with bis(neopentyl glycolato)diboron (494 mg, 2.2 mmol) using the method of Example 20 to give 4-fluoro-3-(pyrimidin-4-yl)phenylboronic acid as a tan solid: MS (ES+) m/z 219 [M+H]+.

Sources & evidence

ORD record
ord-872766b83a17466e86784de232575f61
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Reaction notes

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