Bis(neopentyl glycolato)diboron → HCID 22329528, compound

HRID 586300Notes

Reaction equation

HRID 586300 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[C:13]([F:14])=[CH:12][C:11]([F:15])=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[B:16]1(B2OCC(C)(C)CO2)[O:21]CC(C)(C)C[O:17]1>>[F:14][C:13]1[C:8]([C:4]2[CH:3]=[C:2]([B:16]([OH:21])[OH:17])[CH:7]=[CH:6][CH:5]=2)=[N:9][CH:10]=[C:11]([F:15])[CH:12]=1

Participants

3

Reactant 2

HCID 2734316Bis(neopentyl glycolato)diboronHCID 22329520HCID 22329520, compound

Product 1

HCID 22329528HCID 22329528, compound

Procedure

2-(3-Bromophenyl)-3,5-difluoropyridine (80 mg, 0.30 mmol) was reacted with bis(neopentyl glycolato)diboron (74 mg, 0.33 mmol) using the method of Example 20 to give 3-(3,5-difluoropyridin-2-yl)phenylboronic acid as a tan solid: MS (ES+) m/z 236 [M+H]+.

Sources & evidence

ORD record
ord-1067dd4edbfe4d279b58f3bd6b4a7e38
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Reaction notes

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