Sodium Carbonate → HCID 10268440, compound

Participants

Reaction Steps

This reaction was carried out as described in Example 37, step e, using 1-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl]-1H-[1,2,4]triazole (192 mg, 0.75 mmol), 7-bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (0.1 g, 0.375 mmol), 2 M Na2CO3 (0.75 ml) and tetrakis(triphenylphosphine)palladium(0) (0.022 g) in 1,2-dimethoxyethane (2 ml). The crude residue was purified by flash chromatography (silica gel, 5% MeOH/CH2Cl2) and triturated with Et2O to yield the title compound (68 mg, 55%): 1H NMR (360 MHz, CDCl3) δ 7.72 (1H, t, J 7.8 Hz), 7.76-7.80 (1H, m), 8.09-8.13 (1H, dt, J 7.8, 1.3 Hz), 8.17 (1H, s), 8.57 (1H, t, J 1.9 Hz), 8.67 (1H, s), 8.71 (1H, s), 8.87 (1H, s); MS (ES+) m/z 332 [M+H]+.

Provenance & Evidence