Sodium Carbonate → HCID 86759821, compound

Participants

Reaction Steps

This reaction was carried out as described in Example 37, step e, using 3-[3-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)phenyl]-1-methyl-1H-[1,2,4]triazole (515 mg, 1.9 mmol), 7-bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (0.461 g, 1.73 mmol), 2 M Na2CO3 (1.9 ml) and tetrakis(triphenylphosphine)palladium(0) (0.1 g) in 1,2-dimethoxyethane (4 ml). The crude residue was purified by flash chromatography (silica gel, 5% MeOH/CH2Cl2) and triturated with Et2O to yield the title compound (346 mg, 58%). 1H NMR (360 MHz, CDCl3) δ 4.02 (3H, s), 7.64 (1H, t, J 7.9 Hz), 8.11 (1H, s), 8.16 (1H, dt, J 8.2, 1.6 Hz), 8.21 (1H, dt, J 8.2, 1.6 Hz), 8.71 (1H, s), 8.81 (1H, t, J 1.4 Hz), 8.84 (1H, s); MS (ES+) m/z 346 [M+H]+.

Provenance & Evidence