Sodium Carbonate → HCID 9902886, compound

Participants

Reaction Steps

This reaction was carried out as described in Example 37, step e, using 1-[5-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-2-fluorophenyl]-1H-imidazole (344 mg, 1.67 mmol), 7-bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (0.446 g, 1.67 mmol), 2 M Na2CO3 (1.67 ml) and tetrakis(triphenylphosphine)palladium(0) (0.096 g) in 1,2-dimethoxyethane (6 ml). The crude residue was purified by flash chromatography (silica gel, 3% MeOH(CH2Cl2) and triturated with Et2O to yield the title compound (77 mg, 13%): 1H NMR (360 MHz, CDCl3) δ 7.29 (1H, s), 7.35 (1H, d, J 1.4 Hz), 7.50 (1H, t, J 9.1 Hz), 7.92 (1H, s), 8.04-8.08 (1H, m), 8.30 (1H, dd, J 7.0, 2.1 Hz), 8.64 (1H, s), 8.84 (1H, s); MS (ES+) m/z 349 [M+H]+.

Provenance & Evidence