Sodium Carbonate → HCID 9969811, compound

Participants

Reaction Steps

4-Fluoro-3-(5-fluoropyridin-2-yl)phenylboronic acid (61 mg, 0.25 mmol) was coupled to 7-bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (0.046 g, 0.17 mmol) as described in Example 37, step e, using 2 M Na2CO3 (0.26 ml) and tetrakis(triphenylphosphine)palladium(0) (0.010 g) in 1,2-dimethoxyethane (2 ml). The crude residue was purified by flash chromatography (silica gel, 2.5% MeOH/CH2Cl2) and triturated with Et2O to yield the title compound (23 mg, 35%): 1H NMR (400 MHz, CDCl3) δ 7.39 (1H, dd, J 8.8, 10.8 Hz), 7.51-7.56 (1H, m), 8.89-7.94 (1H, m), 8.14-8.17 (1H, m), 8.63 (1H, d, J 2.7 Hz), 8.66 (1H, s), 8.74 (1H, dd, J 7.4, 2.3 Hz), 8.83 (1H, s); MS (ES+) m/z 378 [M+H]+.

Provenance & Evidence