3-Aminophenylboronic acid → HCID 22329549, compound

Participants

Reaction Steps

This reaction was carried out as in Example 6, step b, using a mixture of 3-aminophenylboronic acid (290 mg, 1.87 mmol) and 7-bromo-3-trifluoromethylimidazo[1,2-b][1,2,4]triazine (250 mg, 0.93 mmol). The residue was purified by flash chromatography (silica gel, 35% EtOAc/isohexane) to give 105 mg (41%) of the title compound: 1H NMR (400 MHz, CDCl3) δ 3.87 (2H, br s), 6.80 (1H, ddd, J 7.9, 2.4, 0.8 Hz), 7.34 (1H, t, J 7.9 Hz), 7.46-7.43 (2H, m), 8.57 (1H, s), 8.77 (1H, s); MS (ES+) m/z 280 [M+H]+.

Provenance & Evidence