HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → [3-fluoro-4-(1H-pyrazol-1-yl)phenyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 1-(2-fluoro-4-nitrophenyl)-1H-pyrazole | HCID 10703514 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | [3-fluoro-4-(1H-pyrazol-1-yl)phenyl]amine | HCID 10725981 | — |
Reaction Steps
A solution of 1-(2-fluoro-4-nitrophenyl)-1H-pyrazole (3 g, 14.5 mmol) and platinum(IV) oxide (100 mg) in ethanol (100 ml) with ethyl acetate (100 ml) was reduced under 40 psi hydrogen for 30 min, then filtered and the solvent removed, to give 5-fluoro-4-(pyrazol-1-yl)phenylamine as a colourless oil: MS (ES+) m/z 178 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936608B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-c6ea542589cb4a498f82b5665b2a8bd8 |
| Source note | uspto-grants-2005_08 |