Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Fluoro-3-nitrobenzene | HCID 9823 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 22330068 | HCID 22330068 | 38% |
Reaction Steps
To a solution of 3-fluoro-1-nitrobenzene (3.37 ml; 31.6 mmol) in NMP (5 ml) was added triethylamine (4.38 ml; 31.6 mmol) and ethyl 1-piperazinecarboxylate (4.63 ml; 31.6 mmol) and the mixture was heated to 120° C. for five days. The cooled mixture was poured into ice-water and a small volume of ethanol was added. Vigorous stirring caused the product to precipitate. The product was filtered off, washed with petroleum ether and dried to leave 6p (3.34 g; 38%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06936613B2 |
|---|
| Source dataset | uspto-grants-2005_08 |
|---|
| ORD ID | ord-9c6e40d37eb74bce827cd3fa5a6af5fc |
|---|
| Source note | uspto-grants-2005_08 |
|---|
