反应详情

温度

80 °C

To a solution of 1-(2-hydroxyethyl)piperazine (5.5 ml; 42.3 mmol) in toluene (50 ml) was added acetic anhydride (4.0 ml; 42.4 mmol). The mixture was heated to 80° C. overnight. The solvent was removed under reduced pressure and the residue was washed several times with a mixture of diethyl ether and petroleum ether (1:1 v/v) to leave 6q1 as an oil (5.2 g; 72%).

1. customThe solvent was removed under reduced pressure
2. washthe residue was washed several times
3. additionwith a mixture of diethyl ether and petroleum ether (1:1 v/v)
4. customto leave 6q1 as an oil (5.2 g; 72%)