Binap, (A+-)- → HCID 20825590, compound

Participants

Reaction Conditions

Reaction Steps

Sodium tert-butoxide (100 mg, 1.04 mmol) was added to a solution of N2-isopropyl-4-methyl-1,2-benzenediamine (100 mg 0.60 mmol) and N-{6-chloro-2-[4-(2-pyridinyl)-1-piperazinyl]-4-pyrimidinyl}-N,N-dimethylamine (100 mg, 0.30 mmol) in 1,4-dioxane (10 mL). Tris(dibenzylidineacetone)dipalladium (8 mg, 0.008 mmol) and 2,2′-Bis(diphenylphosphino)-1,1′binapthyl (10 mg, 0.016 mmol) were added to this mixture and heated at 110° C. for 10 hours. The resulting mixture was cooled to room temperature, concentrated in vacuo, and purified by preparative thin-layer chromatography [eluent: hexane/EtOAc (1:1)], giving the desired product (30 mg, 23%).

Provenance & Evidence