Hydrochloric Acid → HCID 22329462, compound

Participants

Reaction Steps

A mixture of 2-(4-benzyl-1-piperazinyl)-N-(3,4-dichlorophenyl)-6-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-4-pyrimidinamine (100 mg, 0.18 mmol) and 4M HCl (10 mL) in dioxane (20 mL) was stirred at room temperature for 24 hours. The crude product was purified by preparative thin-layer chromatography [eluent: EtOAc/hexane (2:3) with 1% NH3 in methanol], giving the desired product (10 mg, 11%).

Provenance & Evidence