2-Piperazinylpyrimidine dihydrochloride → HCID 9805278, compound

HRID 586421Notes

Reaction equation

HRID 586421 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[CH:21]=[C:20]([N:22]([CH3:24])[CH3:23])[N:19]=[C:18](S(C)=O)[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.Cl.[N:30]1([C:36]2[N:41]=[CH:40][CH:39]=[CH:38][N:37]=2)[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1>ClC1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([NH:15][C:16]2[CH:21]=[C:20]([N:22]([CH3:24])[CH3:23])[N:19]=[C:18]([N:33]3[CH2:34][CH2:35][N:30]([C:36]4[N:37]=[CH:38][CH:39]=[CH:40][N:41]=4)[CH2:31][CH2:32]3)[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 116802722-Piperazinylpyrimidine dihydrochlorideHCID 69751029HCID 69751029, compound

Product 1

HCID 9805278HCID 9805278, compoundYield 42.5%

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A mixture of N4-[3-(benzyloxy)phenyl]-N6,N6-dimethyl-2-(methylsulfinyl)-4,6-pyrimidinediamine (30 mg, 0.078 mmol) and 2-(1-piperazinyl)pyrimidine dihydrochloride (74 mg, 0.312 mmol) in chlorobenzene (2 mL) was heated at reflux for 15 hours. The crude product was purified by preparative thin-layer chromatography [eluent: hexane/EtOAc (7:3)], giving the desired product (16 mg, 42%).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 15 hours
  3. customThe crude product was purified by preparative thin-layer chromatography [eluent: hexane/EtOAc (7:3)]

Sources & evidence

ORD record
ord-d247ce35221340159fc11b1e9a109c53
Source dataset
uspto-grants-2005_08
Patent number
US06936607B2

Reaction notes

Loading…