3,4-Dichloroaniline → HCID 22329441, compound

HRID 586423Notes

Reaction equation

HRID 586423 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[Cl:9])[NH2:5].[Cl:10][C:11]1[N:16]=[C:15](Cl)[CH:14]=[C:13]([Cl:18])[N:12]=1.C([O-])([O-])=O.[Na+].[Na+]>C(O)C.O>[Cl:10][C:11]1[N:16]=[C:15]([NH:5][C:4]2[CH:6]=[CH:7][C:8]([Cl:9])=[C:2]([Cl:1])[CH:3]=2)[CH:14]=[C:13]([Cl:18])[N:12]=1

Participants

6

Reactant 3

HCID 72573,4-DichloroanilineHCID 10340Sodium CarbonateHCID 773782,4,6-Trichloropyrimidine

Product 1

HCID 22329441HCID 22329441, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

A solution of 3,4-dichloroaniline (8.87 g, 54.8 mmol) in ethanol (40 mL) was added to a solution of 2,4,6-trichloropyrimidine (10.0 g, 54.8 mmol) in ethanol (20 mL) followed by aqueous Na2CO3 (4.61 g, 43.5 mmol) at 0° C. The reaction mixture was stirred at room temperature overnight. The crude mixture was diluted with water (100 mL), and the resulting precipitate was filtered and dried (10.2 g, 61%). ESI-MS m/z: 307 (MH+).

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried (10.2 g, 61%)

Sources & evidence

ORD record
ord-e7d1e8cd072a489d8d4ab695f50041c4
Source dataset
uspto-grants-2005_08
Patent number
US06936607B2

Reaction notes

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