Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Amlodipine | HCID 2162 | — |
| Reactant | (R)-camphorsulfonic acid | HCID 131278 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 652969-01-2 | HCID 12991104 | 80.1% |
Reaction Steps
12.25 g (0.03 mol) of amlodipine was dissolved in 50 ml of methanol, cooled to 10° C., and a solution of 7.8 g (0.336 mol) of (1R)-(−)-10-camphor sulfonic acid (Aldrich) in 19.5 mg of methanol was gradually added thereto. 15.4 g (yield: 80.0%) of the title compound in the form of a white crystal was obtained by using the same method described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06936625B2 |
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| Source dataset | uspto-grants-2005_08 |
|---|
| ORD ID | ord-2f051d43e7fc4f18a9e78b6c7d1fe90e |
|---|
| Source note | uspto-grants-2005_08 |
|---|
