Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Amlodipine | HCID 2162 | — |
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 652969-01-2 | HCID 12991104 | 83.2% |
Reaction Steps
12.25 g (0.03 mol) of amlodipine was dissolved in 50 ml of methanol, cooled to 10° C., and a solution of 7.8 g (0.336 mol) of (±)-10-camphor sulfonic acid (Aldrich) in 19.5 ml of methanol was gradually added thereto. 16.0 g (yield: 83.2%) of the title compound in the form of a white crystal was obtained by using the same method described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06936625B2 |
|---|
| Source dataset | uspto-grants-2005_08 |
|---|
| ORD ID | ord-7e6c71bae5f04296b4d4638a90c68f7b |
|---|
| Source note | uspto-grants-2005_08 |
|---|
