HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 586432Generated: October 30, 2026
Ammonium Hydroxide → (+/-)-4-[2-methyl-1-(1H-1,2,4-triazol-1-yl)propyl]-benzenamine
https://huagongshe.com/reaction/586432
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | (+/-)-N-[4-[2-methyl-1-(1H-1,2,4-triazol-1-yl)propyl]phenyl]acetamide | HCID 9903273 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | (+/-)-4-[2-methyl-1-(1H-1,2,4-triazol-1-yl)propyl]-benzenamine | HCID 10900053 | 75.4% |
Reaction Steps
A mixture of (±)-N-[4-[2-methyl-1-(1H-1,2,4-triazol-1-yl)propyl]phenyl]acetamide (0.095 mol) in HCl (3N) (250 ml) was stirred and heated at 60° C. for 5 hours. The mixture was cooled, poured into ice, basified with concentrated NH4OH and extracted with CH2Cl2. The organic layer was dried, filtered off and evaporated. The residue was crystallized from 2-propanone/(C2H5)2O and filtered off, yielding 15.5g (75%) of (±)-4-[2-methyl-1-(1H-1,2,4-triazol-1-yl)propyl]-benzenamine (interm. 2; mp. 117.8° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06936626B2 |
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| Source dataset | uspto-grants-2005_08 |
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| ORD ID | ord-8e8f1f7ea0aa4b939e21c2bc0b2e8200 |
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| Source note | uspto-grants-2005_08 |
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