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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 586577Generated: October 26, 2026

2-Aminothiazole → (2,6-Dimethyl-phenyl)-(6-pyridin-3-yl-imidazo[2,1-b]thiazol-5-yl)-amine

https://huagongshe.com/reaction/586577

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-AminothiazoleHCID 2155—
Reactant3-PyridinecarboxaldehydeHCID 10371—
Reactant2,6-Dimethylphenyl isocyanideHCID 76009—
SolventPerchloric AcidHCID 24247—
Product(2,6-Dimethyl-phenyl)-(6-pyridin-3-yl-imidazo[2,1-b]thiazol-5-yl)-amineHCID 22335596—

Reaction Steps

Compound 20 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-aminothiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) 2,6-dimethylphenylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 3-pyridinecarbaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06936631B2
Source datasetuspto-grants-2005_08
ORD IDord-34c0fb6b47c94b1d8396861b6a9f754f
Source noteuspto-grants-2005_08