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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 586605Generated: October 26, 2026

2-Aminothiazole → Cyclohexyl-[6-(2,5-dimethylphenyl)-imidazo[2,1-b]thiazol-5-yl]-amine

https://huagongshe.com/reaction/586605

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-AminothiazoleHCID 2155—
Reactant2,5-DimethylbenzaldehydeHCID 22015—
ReactantCyclohexyl isocyanideHCID 79129—
SolventPerchloric AcidHCID 24247—
ProductCyclohexyl-[6-(2,5-dimethylphenyl)-imidazo[2,1-b]thiazol-5-yl]-amineHCID 22335571—

Reaction Steps

Compound 51 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-aminothiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2,5-dimethylbenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06936631B2
Source datasetuspto-grants-2005_08
ORD IDord-02ef4ac0e3434f49b3c473c720d88845
Source noteuspto-grants-2005_08