Methanol → HCID 22335623, compound

Participants

Reaction Steps

A solution of 6-(4-fluorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine (prepared according to Laufer et al., 1.11 g, 4 mmol) in CHCl3 (20 ml) is cooled to 0° C. in an ice bath, treated with triethylamine (0.44 g, 4.4 mmol), and diphosgene (0.43 g, 2.2 mmol), dissolved in CHCl3 (5 ml) is added dropwise. After addition is complete, the mixture is stirred at RT for a further 4 h in the cold. After addition of MeOH (4 ml), it is additionally stirred at RT for 16 h. The reaction solution is washed with water, and then with Na2CO3 solution (10%) until acid-free and finally washed again with water. The separated CHCl3 phase is dried using Na2SO4 sicc. and concentrated. As a residue, 1.3 g (100%) of methyl 2-(4-fluorophenyl)-1-phenyl-6,7-dihydro-5H-pyrrolizine-3-carboxylate are obtained (GC. 93%). The substance is used in the next reaction step without further purification.

Provenance & Evidence