HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(4-fluorophenyl)ethan-1-one → HCID 15390832, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-Benzyl-2,3-dihydro-1H-pyrrole | HCID 12805115 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 15390832 | HCID 15390832 | — |
Reaction Steps
According to the procedure of Laufer et al. (J. Med. Chem. 1994, 37, 1894-1897), first 2-bromo-1-(4-fluorophenyl)ethanone (10.8 g, 0.05 mol) in portions and then NaHCO3 (5.0 g, 0.06 mol) are added to a solution of 2-benzylpyrroline (Example 1a, 15 g, 80%, 0.075 mol) in ethanol (150 ml) in a round-bottomed flask. The reaction mixture is stirred for 24-60 h with exclusion of light; during this time the temperature of the solution is kept between 30-40° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06936632B2 |
| Source dataset | uspto-grants-2005_08 |
| ORD ID | ord-87ab5c0c94804f30bfbb78c853876fcd |
| Source note | uspto-grants-2005_08 |