Carbon Dioxide → HCID 22335624, compound

Participants

Reaction Steps

1-(3-Carboxymethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-2-yl)cyclohexanecarboxylic acid (1.5 g, 3.7 mmol) is immersed in an oil bath of 150° C. for 30 min in a 25 ml flask. The release of CO2 is checked via a bubble counter. The still warm melt is digested with diisopropyl ether (15 ml). The insoluble crystalline residue is filtered off with suction and dried. 0.84 g (82% of theory) of decarboxylation product 6-cyclohexyl-5-methyl-7-phenyl-2,3-dihydro-1H-pyrrolizine (TLC: SiO2, ether-n-hexane (1:1): starting material Rf 0-0.2, product 0.9) is obtained.

Provenance & Evidence