Ethanol → HCID 22335612, compound

Participants

Reaction Steps

7-(4-Chlorophenyl)-6-phenyl-2,3-dihydro-1H-pyrrolizine (Example 21 b, 1.5 g, 5.1 mmol), dissolved in THF (10 ml), is treated with triethylamine (0.7 ml, 0.51 g, 5 mmol). A solution of diphosgene (0.5 g, 2.5 mmol), dissolved in THF (5 ml), is added dropwise to this solution at RT, it is stirred for 12 h, ethanol (abs., 3 ml, 2.37 g, 51 mmol) and triethylamine (0.7 ml, 0.51 g, 5 mmol) are added, and the mixture is stirred at RT for a further 72 h. The reaction mixture is concentrated in vacuo, and the residue is crystallized from EtOH and dried.

Provenance & Evidence