Imidazole → HCID 22335733, compound

Participants

Reaction Steps

tert-Butyldimethylsilyl chloride (2.7 g, 17.5 mmol) was added to the solution of Intermediate 2 (3 g, 11.6 mmol) and imidazole (1.6 g, 23.2 mmol) in 10 mL of DMF. The mixture was then stirred for 16 h at room temperature. After quenching with water, the mixture was extracted with ether (3×10 mL), washed with brine (1×10 mL), dried (MgSO4) and concentrated to give a crude brown oil. The crude product was purified by flash chromatography using 10% EtOAc in hexane to give the title compound (3 g, 70% yield) as a colorless oil:

Provenance & Evidence