Methyl iodide → HCID 69740307, compound

HRID 586651Notes

Reaction equation

HRID 586651 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[C@H:6]([CH2:7][OH:8])[C:5]1([CH3:23])[C:9]1[CH:18]=[CH:17][C:16]2[C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][C:12]([CH3:22])([CH3:21])[C:11]=2[CH:10]=1.[Si](OCC1[C@@H](CO)C1(C)C1C=CC2C(C)(C)CCC(C)(C)C=2C=1)(C(C)(C)C)(C)C.CI>>[CH3:1][O:2][CH2:3][CH:4]1[C@@H:6]([CH2:7][OH:8])[C:5]1([CH3:23])[C:9]1[CH:18]=[CH:17][C:16]2[C:15]([CH3:20])([CH3:19])[CH2:14][CH2:13][C:12]([CH3:22])([CH3:21])[C:11]=2[CH:10]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 69738373HCID 69738373, compoundHCID 131725079HCID 131725079, compound

Product 1

HCID 69740307HCID 69740307, compoundYield 40%

Procedure

Following a procedure similar to that for the preparation of Intermediate 6a using Intermediate 5 as the starting material and methyl iodide as the alkylating reagent provided the title compound as a colorless oil (67 mg, 40% yield):

Sources & evidence

ORD record
ord-5952ac0828294bbebeb498bb4ecdc2b7
Source dataset
uspto-grants-2005_08
Patent number
US06936636B2

Reaction notes

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