Hydrochloric Acid → HCID 131725087, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydroxide solution (1N, 1 mL) was added to a solution of Compound 16a (59 mg, 0.13 mmol) in 4 mL of THF/MeOH (1:1) at 50° C. After stirring at 50° C. for 16 h, the mixture was diluted with ethyl acetate (10 mL) ad acidified with 1 mL of 1 HCl at 0° C. The organic layer was then washed with brine (1×5 mL), dried (Na2SO4) and concentrated. The residue was purified by flash chromatography using 30% EtOAc in hexane to give the title compound (43 mg, 79% yield) as a white solid:

Provenance & Evidence