Methanol → Benzyl methyl ether

To a solution of 1.57 g (10 mmol) of benzyl chloride in 40 ml of benzene, 5.57 g (15 mmol) of the tris(dimethylamino)[tris(dimethylamino)phosphoranilideneamino]phosphonium salt of methanol, said salt having had been synthesized in a similar manner as in Example 1, were added at 0° C., followed by a reaction at room temperature for 3 hours. Water (50 ml) was then added to the reaction mixture to terminate the reaction. An organic layer was separated, washed successively with 20 ml of water and 20 ml of a saturated aqueous solution of sodium chloride, and then concentrated to dryness. The resulting liquid compound was distilled, whereby benzyl methyl ether, the target compound, was obtained as a colorless liquid compound in an amount of 1.13 g. Its yield was 93%.

1. customhaving had been synthesized in a similar manner as in Example 1
2. additionwere added at 0° C.
3. customfollowed by a reaction at room temperature for 3 hours
4. customto terminate
5. customthe reaction
6. customAn organic layer was separated
7. washwashed successively with 20 ml of water and 20 ml of a saturated aqueous solution of sodium chloride
8. concentrationconcentrated to dryness
9. distillationThe resulting liquid compound was distilled

ORD record

ord-997bf4f7a2b34947b56a3a5f317e00e2

Source dataset

uspto-grants-2005_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06936684B2