2-Fluoro-5-nitrobenzonitrile → HCID 10142493, compound

HRID 586774Notes

Reaction equation

HRID 586774 reaction equation
[NH2:1][C:2](=[N:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][N:18]([C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:28]3[CH2:32][CH2:31][S:30][S:29]3)=[O:22])[CH2:17][CH2:16]2)=[C:11]([CH3:33])[CH:10]=1)[C:3]1[S:4][CH:5]=[CH:6][CH:7]=1.FC1C=CC([N+]([O-])=O)=CC=1C#[N:38]>>[NH2:1][C:2](=[N:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:16][CH2:17][N:18]([C:21]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH:28]3[CH2:32][CH2:31][S:30][S:29]3)=[O:22])[CH2:19][CH2:20]2)=[C:11]([C:33]#[N:38])[CH:10]=1)[C:3]1[S:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5194172-Fluoro-5-nitrobenzonitrileHCID 10185551HCID 10185551, compound

Product 1

HCID 10142493HCID 10142493, compoundYield 12%

Procedure

The experimental protocol used is the same as that described for the compound of Example 6, 2-fluoro-5-nitrobenzonitrile replacing 2-fluoro-5-nitrotoluene. A yellow solid is obtained (yield 12%).

Workup

  1. customA yellow solid is obtained (yield 12%)

Sources & evidence

ORD record
ord-5041a681486f42878b42cf3cda674be8
Source dataset
uspto-grants-2005_08
Patent number
US06936715B2

Reaction notes

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